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“My research group was among the first to investigate whether the skin is capable of producing endocannabinoids, and apparently most, if not all, skin functions are controlled to a certain extent by the local skin endocannabinoid system,” says Tamas Biro, PhD, director of the immunology department at the University of Debrecen, Hungary, and an adviser for Phytecs, a biotech company that researches and develops products targeting the endocannabinoid system for the medical, nutraceutical, and cosmetic industries. “This includes the skin barrier, which is very important for moisture retention, sebum production, and sweat-gland function, as well as skincentric sensory functions such as pain and itch. But perhaps most important, it appears that the endocannabinoid system controls skin inflammation—so if an inflammatory or irritation challenge assaults the skin, the endocannabinoid system fights against it.” This could potentially make cannabinoids useful antiaging ingredients, and, Biro speculates, due to their capacity to regulate sebum, they might turn out to be especially potent tools for fighting acne, although studies are still in the preclinical stages: “We found that when we applied CBD to human skin cells in a Petri dish,” he says, “it prevented the inflammation and high production of sebum” associated with breakouts.

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